Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N(6)-Carboxymethyllysine

We found that the microbiota influenced critical characteristics linked with aging. We compared microglia from young adult and aged mice housed under germ-free and specific-pathogen-free conditions. Moreover, we examined the impact of CML treatment on young adult mice.我们发现，微生物群（microbiota）可影响与衰老相关的关键特征。本研究比较了饲养于无菌（germ-free）与无特定病原体（specific-pathogen-free）环境下的年轻成年小鼠及老年小鼠的小胶质细胞（microglia）。此外，我们还考察了慢性髓系白血病（CML）处理对年轻成年小鼠的影响。