Transcriptome data of B cells from patients with multiple sclerosis and healthy controls

We analyzed the transcriptome profile of B cells from patients with relapsing-remitting multiple sclerosis (RRMS), patients with primary progressive multiple sclerosis (PPMS) and healthy individuals. High-density Clariom D Arrays for human were used to quantify the transcript levels. This GEO entry provides the processed Clariom D microarray data from the gene-level and exon-level workflows. EDTA blood samples (n=121) were taken from MS patients (n=63) and healthy controls (n=28). Up to four blood samples were collected per patient. Seven patients were about to switch to an immune reconstitution therapy (IRT). The other RRMS patient samples were taken under therapy with alemtuzumab (n=38), natalizumab (n=29) or cladribine (n=6). Untouched B cells were isolated from each blood sample, and total RNA was extracted, labeled and hybridized to Clariom D microarrays to obtain gene-level and exon-level expression profiles.