Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, BENZAMIDINE, GLYCEROL, ... Authors: Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. Deposit date: 2012-02-19 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012

本数据集的研究主题为：小分子配体结合Ras蛋白的独特口袋并抑制SOS介导的核苷酸交换活性。本数据集收录的相关物质包括：5'-二磷酸单硫代鸟苷（5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE）、苯甲脒（BENZAMIDINE）、甘油（GLYCEROL）等。作者名单如下：Oh, A、Maurer, T、Garrenton, L.S、Pitts, K、Anderson, D.J、Skelton, N.J、Fauber, B.P、Pan, B、Malek, S、Stokoe, D、Ludlam, M、Bowman, K.K、Wu, J、Giannetti, A.M、Starovasnik, M.A、Mellman, I、Jackson, P.K、Ruldolph, J、Fang, G、Wang, W。入库日期：2012-02-19；发布日期：2012-04-04；最后修改日期：2024-02-28。实验方法为X射线衍射（X-RAY DIFFRACTION），分辨率达1.85埃（Å）。引用信息：《小分子配体结合Ras蛋白的独特口袋并抑制SOS介导的核苷酸交换活性》，发表于《美国国家科学院院刊（Proc.Natl.Acad.Sci.USA）》，2012年，第109卷。