X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Yan, S, Wang, Z.M. Deposit date: 2008-08-20 Release date: 2009-09-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res., 69, 2009

人促分裂原活化蛋白激酶激酶1（mitogen-activated protein kinase kinase 1，MEK1）与强效抑制剂RDEA119及MgATP形成复合物的X射线晶体结构。
描述项：腺苷-5'-三磷酸、双特异性促分裂原活化蛋白激酶激酶1、镁离子……。
作者：Yan, S、Wang, Z.M.
提交日期：2008-08-20
发布日期：2009-09-01
最后修改日期：2023-08-30
实验方法：X射线衍射（分辨率2.5埃）
引用文献：RDEA119/BAY 869766：一种用于癌症治疗的强效、选择性MEK1/2变构抑制剂。《癌症研究》（Cancer Res.），第69卷，2009年。