Effects of therapy with mDEF201 and cidofovir on survival of mice from a vaccinia virus (WR strain) respiratory infection.

aThe doses of mDEF201 are in PFU/mouse units, whereas the dose of cidofovir is in mg/kg/day units. mDEF201 was given as a single intranasal treatment, as was the placebo Cidofovir was administered by intraperitoneal route once a day for two days. For consistency with the other groups, the cidofovir group also received intranasal saline at 24 h.bMean day of death for mice that died on or before day 21 of the infection. The mice were inoculated intranasally with 1×105 PFU of virus to initiate the infection.**P***P