TPE genes containing major sequence changes encoding hypothetical proteins.

T. p. ssp. pertenue (TPE) genes encoding hypothetical proteins containing six or more amino acid changes and/or major sequence changes between all studied T. p. ssp. pertenue and all T. p. ssp. pallidum strains are shown. CHP, conserved hypothetical protein; HP, hypothetical protein; TCHMP, treponemal conserved hypothetical membrane protein; TCHOMP, treponemal conserved hypothetical outer membrane protein; TCHP, treponemal conserved hypothetical protein.aD, deletion; fr. mut., frameshift mutation; I, insertion; MSC (major sequence changes) are defined in Table 1; S, substitution.bGene expression rate in Nichols strain grown in rabbits. The gene expression rates were taken from [58].cThe gene was shown to contain frameshift mutations or MSC in the genome of Treponema paraluiscuniculi Cuniculi A [33].dThe corresponding protein was identified as an antigen [54].eThe corresponding protein was identified as a lipoprotein [55].fDetected recombination.gThe selection test was calculated using the Kumar model [47] using MEGA4 [48] software.