Supporting data for "A Systematic Investigation on Chinese Medicine and particular Shihu-Yuye Decoction, a Classic Chinese Medicine Formula, in Treating Diabetic Nephropathy and the Underlying Mechanisms "

Diabetic nephropathy (DN), which is known as a major microvascular diabetic complication, is the deterioration of kidney function and the leading cause of end-stage renal disease. Persistent hyperglycemia is the major reason of kidney dysfunction associated with Diabetes mellitus. Statistics showed that there are about 171 million diabetes worldwide and approximately 40% diabetic patients result in DN. Report showed that DN can be improved by nourishing kidney Yin through Chinese medicine.
Yuye Decoction (YYD) is an ancient formulation in Chinese medicine. Dendrobium officinale (DO) can nourish kidney Yin based on Pharmacopoeia of China recorded. Therefore, we hypothesize that DOY, which is the combination of DO and YYD, can treat DN. Transforming growth factor β1 (TGF-β1) signaling pathway plays a pivotal role in the initiation and progression of DN. In this study, we aim to investigate the effect of DOY on DN and TGF-β1 signaling pathway.

糖尿病肾病（DN），亦称主要微血管糖尿病并发症，乃肾脏功能衰退及终末期肾病的主要诱因。持续的血糖过高是糖尿病 mellitus 相关肾脏功能障碍的主要原因。据统计，全球约有1.71亿糖尿病患者，其中约40%的患者发生DN。报告显示，通过中医滋肾阴的方法可以改善DN。玉液汤（YYD）是中医古方之一。根据《中国药典》记载，铁皮石斛（DO）具有滋肾阴之功效。因此，我们假设由DO与YYD组合而成的DOY，能够治疗DN。转化生长因子β1（TGF-β1）信号通路在DN的启动和进展中起着至关重要的作用。本研究旨在探究DOY对DN及TGF-β1信号通路的影响。