BindingDB Entry 50046130: Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3.

Small molecule binding data for protein AKT/p21CIP1, Activin receptor-like kinase 3 (ALK-3), C-RAF, CAMK2A, CDK2/Cyclin A/Cyclin A1, Casein kinase I isoform delta, Dual specificity mitogen-activated protein kinase kinase 1, Ephrin receptor, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase 9 (MLK1), Neurotrophic tyrosine kinase receptor, Protein kinase C alpha type, Protein kinase C theta type, Rho-associated protein kinase, Ribosomal protein S6 kinase (P70S6K), Serine/threonine-protein kinase Aurora-C, Serine/threonine-protein kinase Chk1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CSK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, Tyrosine-protein kinase TEC, Tyrosine-protein kinase ZAP-70, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and Voltage-gated potassium channel, Uniprot O14757, O60674, P00519, P00533, P04049, P04626, P04629, P08069, P17252, P20248, P23443, P23458, P24941, P29317, P31749, P36894, P41240, P42680, P43403, P43405, P48730, P49841, P52333, P53779, P78396, P80192, Q02750, Q02763, Q04759, Q05397, Q06187, Q08881, Q12809, Q13233, Q13464, Q9NWZ3, Q9UQB9, and Q9UQM7