Survival and prediction of distant recurrence in glioblastoma

Background: Glioblastoma is the most prevalent and aggressive primary tumor of the Nervous System. The condition manifests with a high rate of recurrence, predominantly in a localized pattern. The impact of distant recurrence on survival and the associated factors are a controversial subject. This study aims to determine whether the pattern of distant recurrence exerts any influence on progression-free survival, survival after first progression and overall survival in patients with de novo glioblastoma and low residual tumor volume (RTV<5cc). It also aims to identify which factors predict distant recurrence. Methods: A retrospective single-center cohort study included patients aged 18 years or over with de novo glioblastoma and RTV<5cc after histological diagnosis, who were treated between 2017 and 2023 in our center. Kaplan-Meier curves were utilized for time-to-event analyses. Risk factors were assessed by univariable analysis and logistic regression.