EVLncRNAs

Long noncoding RNAs (lncRNAs) have emerged as crucial regulators across diverse biological processes and diseases. While high-throughput sequencing has enabled lncRNA discovery, functional characterization remains limited. The EVLncRNAs database is the first and exclusive repository for all experimentally validated functional lncRNAs from various species. After previous releases in 2018 and 2021, this update marks a major expansion through exhaustive manual curation of nearly 25,000 publications from May 15, 2020, to May 15, 2023. It incorporates substantial growth across all categories: a 154% increase in functional lncRNAs, 160% in associated diseases, 186% in lncRNA-disease associations, 235% in interactions, 138% in structures, 234% in circular RNAs, 235% in resistant lncRNAs, and 4724% in exosomal lncRNAs. More importantly, it incorporated additional information include functional classifications, detailed interaction pathways, homologous lncRNAs, lncRNA locations, COVID-19, and phase-separation and organoid-related lncRNAs. The web interface was substantially improved for browsing, visualization, and searching. ChatGPT was tested for information extraction and functional overview with its limitation noted. EVLncRNAs 3.0 represents the most extensive curated resource of experimentally validated functional lncRNAs and will serve as an indispensable platform for unravelling emerging lncRNA functions. The updated database is freely available at https://www.sdklab-biophysics-dzu.net/EVLncRNAs3/.

长链非编码RNA（long noncoding RNAs，lncRNAs）已被证实是参与多种生物学过程与疾病的关键调控因子。尽管高通量测序技术已推动了lncRNA的发现进程，但对其功能的注释仍十分有限。EVLncRNAs数据库是首个且唯一收录来自不同物种、经实验验证的功能性lncRNA的专用资源库。继2018年与2021年发布的两个版本后，本次更新通过对2020年5月15日至2023年5月15日期间的近25000篇文献进行全面人工审编，实现了规模的大幅扩充。各分类数据均实现了显著增长：功能性lncRNA数量提升154%，相关疾病数量提升160%，lncRNA-疾病关联条目提升186%，相互作用数据提升235%，结构数据提升138%，环状RNA（circular RNAs）条目提升234%，耐药性lncRNA提升235%，外泌体lncRNA更是提升了4724%。更重要的是，本次更新新增了多项信息：包括功能分类、详细的相互作用通路、同源lncRNA、lncRNA的定位信息、新型冠状病毒肺炎（COVID-19）相关数据，以及相分离和类器官相关的lncRNA。数据库的网页界面也进行了全面优化，以提升浏览、可视化与检索功能。团队还测试了ChatGPT在信息提取与功能概述方面的应用，并注明了其局限性。EVLncRNAs 3.0是目前收录经实验验证的功能性lncRNA最全面的人工审编资源库，将成为解析新兴lncRNA功能的不可或缺的研究平台。本次更新后的数据库可通过https://www.sdklab-biophysics-dzu.net/EVLncRNAs3/免费访问。

搜集汇总

背景与挑战

背景概述

EVLncRNAs 是一个专注于经实验验证的功能性长链非编码RNA（lncRNA）的数据库，为同类资源中首个且最全面的手动整理库。其3.0版本通过系统整理近2.5万篇文献，大幅扩展了数据规模，新增了功能分类、相互作用途径等多种信息类别。该数据库提供免费访问，旨在支持lncRNA功能的深入研究。