Immunomodulatory activities of peptides IDR-HH2, IDR-1002 and IDR 1018 in human peripheral blood mononuclear cells (PBMC).

Cells were stimulated with 20 µg/ml of peptide. 1Experiments were performed 2–4 times and means are presented. All values for peptide treated cells represent significant induction relative to the untreated control (p<0.05) for the two chemokines MCP-1 and Gro-α, and significant reduction in LPS stimulated TNF-α relative to the LPS-treated but peptide-untreated control. There was no significant induction of TNF-α by the peptides themselves. The data for IDR-1018 are consistent with those presented in Wieczorek et al [19].