GABRB2 haplotype association in psychosis severity-based subgroups.

The PANSS score-based groups consist of the full Beijing SCZ cohort (‘All’) and its partitioned ‘High score’ and ‘Low score’ subgroups derived by applying the K-Means clustering function to the PANSS scores for positive symptoms. The antipsychotics dosage-based groups consist of the full US SCZ cohort (‘All’) and its partitioned ‘High dosage’ (>5 mg/day) and ‘Low dosage’ (≤5 mg/day) groups derived based on the daily standard maintenance antipsychotics dosage of 5 mg fluphenazine equivalent. The p-values were obtained from case-control association analysis using the likelihood ratio test. Significant p values (paPairwise haplotypes with component SNPs indicated by X.