Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide [RNA-Seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE234318
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To investigate the effect of SIRT2 inhibition on global transcriptomics profile, we inhibited Sirt2 using small molecules (AGK2) Our analysis reports phenotype-reversal of gliomas as well as induction of terminal differentiation program. Comparative gene expression profiling analysis of RNA-seqdata for murine neuroprogenitor cells (Tp53-/- and Atrx-/- ) and HDAC inhibitiors (AGK2)
创建时间：
2023-06-17
