Protective effect and occasion of Lactobacillus paracasei 207-27 administration on colitis in antibiotic-exposed mice in early life

This study aimed to investigate the possible protective effect and mechanism of short- and long-term applications of Lactobacillus paracasei (L. paracasei) 207-27 for ameliorating gut microbiota disorders due to early life antibiotic exposure in mice with dextran sulphate sodium (DSS)-induced colitis. We here intervened neonatal mice with ceftriaxone, and L. paracasei 207-27 was administered 2h following antibiotic administration . L. paracasei 207-27 were used for continuous gavage for 3 and 6 weeks. The first and second batches of mice were sacrificed on days 21, and day 46 following a 4-day intervention with 3% DSS to induce colitis.