Epigenetic regulation of leaf development

Balanced development of adaxial and abaxial domains in leaf primordia is critical for the formation of flat symmetric leaf lamina. Leaves develop as lateral organs from the peripheral zone of a shoot apical meristem. The AS1-AS2 is regarded as a key regulator for the proper confinement of the stem cell fate and establishment of the adaxial-abaxial axis in Arabidopsis thaliana. It is important to analyze the molecular mechanisms of epigenetic regulation of direct targets of AS1-AS2 to understand leaf development in dicot.