Molecular pathways and putative transcription regulatory networks affected during cardiac aging.

Overview of differential gene expression analysis between 10 days and 40 days adult cardiac tubes. Enrichment p values were calculated using a test based on hypergeometric distribution.(1)Statistically significantly deregulated genes between 10 and 40 day-old dissected hearts were determined using Limma software from normalized expression data (See Table S1 and S2).(2)GO term enrichments were determined using the Flymine database (www.flymine.org) (see Table S5 for details).(3)[13]; See Table S6 for details.(4)[14]; See Table S7 for details.(5)[17], [18]; see Table S9 for details.(6)Transcriptional regulatory network were predicted with cisTargetX (http://med.kuleuven.be/cme-mg/lng/cisTargetX/.) The z score of the most representative TF-binding motif is indicated for each motif family. (See Table S8 for details).