Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009 Descriptor: 1,2-ETHANEDIOL, 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine, AMMONIUM ION, ... Authors: Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. Deposit date: 2019-10-02 Release date: 2019-10-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J.Med.Chem., 63, 2020

与化合物M4K2009结合的ACVR1（ALK2）激酶晶体结构。组成描述：1,2-乙二醇、1-[4-[4-甲基-5-(3,4,5-三甲氧基苯基)吡啶-3-基]苯基]哌嗪、铵离子…… 作者：Adamson, R.J.、Williams, E.P.、Smil, D.、Burgess-Brown, N.、von Delft, F.、Arrowsmith, C.H.、Edwards, A.M.、Bountra, C.、Bullock, A.N.。沉积日期：2019-10-02；发布日期：2019-10-16；最后修改日期：2024-01-24。实验方法：X射线衍射（分辨率1.42 Å）。引用文献：《利用开放科学药物发现模型开发可穿透中枢神经系统的ALK2抑制剂治疗弥漫内生型桥脑胶质瘤》，《药物化学杂志》，2020年，第63卷。