Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy [RNA-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99175
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资源简介：
Purpose: Characterization of mechanism and vulnerability of BET protein dependency in GBM cells. Methods: ChIP-seq and RNA-seq were performed on GBM cells at different time points following treatment with dBET6, a novel BET protein degrader. The transcriptome responses of parental and JQ1-resistant U87 cells to JQ1 and dBET6 were compared as well. Result: This study reveals crucial functions of BET proteins and provides the rationale and therapeutic merits of targeted degradation of BET proteins by dBET6 in GBM. RNA-Seq of U87 Parental and JQ1-Resistant cell lines in response to dBET6 and JQ1
创建时间：
2021-07-25
