Transcriptome changes induced by perturbed expression of circRNA hsa_circ_0062682 in HCC cell lines. Transcriptome changes induced by perturbed expression of circRNA hsa_circ_0062682 in HCC cell lines

Circular RNAs (circRNAs) have been shown to play an important role in the pathogenesis of hepatocellular carcinoma (HCC). By implementing available transcriptomic analyses of HCC patients, we identified an upregulated circRNA hsa_circ_0062682. The aim of the study was to evaluate the oncogenic potential of this circRNA in HCC model cell lines. Using microarrays we evaluated the transcriptome changes induced by perturbation of circRNA expression. Overall design: We have performed a transient overexpression of hsa_circ_0062682 in Huh-7 and generated a stable knockdown of hsa_circ_0062682 in SNU-449 cell lines.