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A primate-specific ELOA3 gene cluster augments sensitivity to BET bromodomain inhibition

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https://www.ncbi.nlm.nih.gov/sra/SRP389085
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We have identified a cluster of ELOA3 gene homologs that are activated upon treatment with BET bromodomain inhibitors and mediate sensitivity to BET inhibition. Overall design: We have performed ChIP-seq for ELOA3, RNA polymerase II (RNAPII) and other transcription elongation factors. In addition we have performed RNA-sequencing in ELOA3 loss-of-function and gain-of-function experiments.
创建时间:
2023-11-30
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