Transcriptomic changes in mice granulosa cells in the presence of simvastatin and mevalonic acid

In vitro follicle culture, simvastatin was found to inhibit follicle development. Mevalonic acid may be a key metabolite of follicle development, and was able to rescue the influence of simvastatin on follicle development. Transcriptome sequencing was used to explore possible causes of these effects.