Swiss consortium in macromolecular X-ray crystallography structure determination for academic researchers: EPFL, UNIL, UNIGE, Zurich and SL

This proposal builds upon the foundation established in BAG MX 2521 and represents a collaborative effort among prominent Swiss academic institutions, including EPFL, UNIL, UNIGE and SLS. Under the leadership of Dr. Florence Pojer, the head of EPFL's Protein Production and Structure core facility, this initiative aims to streamline and enhance the process of determination of macromolecules structures by X-ray crystallography. Notably, the automated data collection established at ESRF has revolutionized our current pipeline, enabling the analysis of over 1000 crystals and the finalization at high-resolution of around 40 different structures in the past year alone. These achievements span diverse projects ranging from drug discovery to the design of novel protein folds. In addition, two PIs from University of Zurich, with expertise in structural biology, are joining this BAG.