pdb

PDB file WT.pdb contains the last frame from 10 ns molecular dynamics simulation alpha7-AChBP chimera (PDB 3SQ6). Only two adjacent subunits were subjected to simulations. PDB files with names E185V, E189G, F187S, L119D, Q117T, R186I, S184N and Y118W contain the last frame from molecular dynamics simulation of alpha7-AChBP chimera with the respective mutations (residues numbered according to human alpha7 nAChR). PDB files F104.pdb and V104_mutant.pdb contain structures in which 104th residue of alpha7 AChBP chimera was changed either to phenylalanine (as in actual human alpha7 nAChR) or to valine (as in alpha9 nAChR).蛋白质数据库（Protein Data Bank，PDB）文件WT.pdb包含了α7-AChBP嵌合体（alpha7-AChBP chimera，PDB条目3SQ6）的10纳秒分子动力学模拟（molecular dynamics simulation）的最后一帧，本次模拟仅针对两个相邻的亚基开展。命名为E185V、E189G、F187S、L119D、Q117T、R186I、S184N及Y118W的PDB文件，均收录了带有对应突变的α7-AChBP嵌合体的分子动力学模拟最后一帧，其氨基酸残基编号依据人类α7烟碱型乙酰胆碱受体（alpha7 nAChR）确定。PDB文件F104.pdb与V104_mutant.pdb所包含的结构中，α7-AChBP嵌合体的第104位残基分别被突变为苯丙氨酸（对应天然人类α7烟碱型乙酰胆碱受体）或缬氨酸（对应α9烟碱型乙酰胆碱受体（alpha9 nAChR））。