Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex

Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. Deposit date: 2023-03-15 Release date: 2024-01-31 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity. Nat Commun, 14, 2023拉坦前列素（Latanoprost）结合的前列腺素F2α受体-miniGq-Nb35复合物的冷冻电镜（Cryo-EM）结构 描述项：鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ2、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β1、鸟苷酸结合蛋白G(s)亚基α短亚型…… 作者：Lv, X、Gao, K、Nie, J、Zhang, X、Zhang, S、Ren, Y、Li, Q、Huang, J、Liu, L、Zhang, X、Sun, X、Zhang, W、Liu, X 提交日期：2023-03-15 发布日期：2024-01-31 最后修改日期：2024-11-06 实验方法：电子显微镜（分辨率3.4 Å） 引用文献：人前列腺素F2α受体的结构揭示配体与G蛋白选择性机制。《自然-通讯（Nat Commun）》，14卷，2023年