human oral metagenome Raw sequence reads

Early Childhood Caries (ECC), especially Severe Early Childhood Caries(S-ECC), may seriously affect children's physical and mental health. According to the previous survey, 81.3% caries are concentrated in 24.8% of children, which indicates a population of high risk and great challenges to pedodontists.Oral bacteria, especially the plaque community is one of the conditions for the occurrence of dental caries. High throughput sequencing techniques now enable us to explore the microbial diversity at the level of DNA, and to further understand their roles. we compared the plaque microbial profiles of healthy young children and those with caries by using high-throughput sequencing, trying to reveal the potential pathogenic bacteria and pathogenesis.