Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)

Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment of human IgG1 Authors: Van, V, Tolbert, W.D, Pazgier, M. Deposit date: 2018-02-27 Release date: 2019-03-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding. Structure, 2020

人源IgG1的Fc片段LALA突变体（L234A、L235A）晶体结构（晶型2）。结构描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，对应人源IgG1的Fc片段。作者：Van V、Tolbert W.D、Pazgier M.。沉积日期：2018-02-27；发布日期：2019-03-06；最后修改日期：2024-10-16。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.44 Å。引用文献：《抗原诱导的人源IgG1 Fc变构变化增强低亲和力Fcγ受体结合》，《Structure》，2020年