Effect of selective inhibitors of NOS (L-NOARG), SK3 (apamin) and IK1 channels (TRAM 34), and combined inhibition of SK3/IK1 channels (A+T) on the ACh and SNAP-induced vasodilation in coronary arteries from LZR and OZR.

Values represent mean ± S.E.M. of the number n of individual arteries. pEC50 is –logEC50. Emax is maximal relaxation expressed as percentage of 5-HT-induced precontraction. ΔBT; is the increase in basal tension expressed as percentage of KPSS-induced contraction. Significant differences from controls were analyzed using paired t test; aP 0.05; bP 0.01; cP 0.001 vs control; or one way ANOVA followed by a Bonferroni test for across-group comparisons; #P 0.05 vs A+T-treated LZR; †P 0.05 vs TRAM34-treated LZR.Effect of selective inhibitors of NOS (L-NOARG), SK3 (apamin) and IK1 channels (TRAM 34), and combined inhibition of SK3/IK1 channels (A+T) on the ACh and SNAP-induced vasodilation in coronary arteries from LZR and OZR.