Epstein-Barr virus positive gastric cancer involves enhancer activation through ATF3
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141385
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ATF3 binding sites on the genome and histone modification arround the ATF3 binding sites were analized by ChIP-seq. Regulation of gene expression by ATF3 on active enhacer regions were analyzed by knocked down of ATF3. Human gastric cancer cell lines MKN7 (MKN7_WT), Epstein-barr virus infected MKN7 (MKN7_EB), NCC24 and SNU719 were transfected ATF3 targeted or non-targeted shRNA lentivirus (shATF3 or shNON respectively) followed by drug selection with puromycin for 2 days. Total RNA was extracted after the drug selection for RNA-seq. MKN7_WT cells were treated with 30 micro mol/L of CDDP for 2 days to induce ATF3 followed by ChIP.
创建时间：
2020-05-26
