Agmatine treatment promoted remyelination following SCI.

(A) Myelin sheath formation in white matter of normal and injured spinal cord was observed by transmission electron microscope (TEM) (1,0000x). The myelination of white matter was ultrastructurally improved with less degenerated myelin in the Agm treated group while swollen axons with broken myelin sheaths were found across the degenerative white matter in the lesioned area in the EC group at 14 DPI. (B) Luxol fast blue staining results showed a remarkable increase of myelin (blue) and neuron (violet) stained cells indicating the reconstruction of lost myelin and neurons in the Agm treated group compared with the EC group at 14 and 35 DPI. Scale bars: 20 µm.