Rattus norvegicus Genome sequencing and assembly. Meibomian gland cells

Meibomian gland dysfunction(MGD) is a chronic ocular surface disease with a complex pathogenesis, whose main clinical manifestations are meibomian gland obstruction or/and lipid abnormalities. We established meibomian gland obstruction model rats. Our model explored the mechanism of MGD due to meibomian gland obstruction solely.To verify the abnormal lipid metabolism in MG-obstructive rats and clarify the pathogenesis of MGD due to meibomian gland obstruction (MGO), mRNA sequencing was performed.