Data and code from: High-concentration MEHP triggers mtDNA depletion in undifferentiated HepaRG and C2C12 cultures and disrupts mitochondrial homeostasis in both HepaRG culture states
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https://datadryad.org/dataset/doi:10.5061/dryad.c59zw3rpr
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资源简介:
This dataset contains bioenergetics data generated from undifferentiated
and differentiated HepaRG cell culture models following mono(2-ethylhexyl)
phthalate (MEHP) treatment. Data include normalized Seahorse XFp Mito
Stress Test measurements, including oxygen consumption rate (OCR) and
extracellular acidification rate (ECAR), provided as structured
comma-separated value (.csv) files. The dataset includes experimental
variables such as treatment condition (MEHP/plus vs. vehicle/minus), cell
differentiation state, time point, and normalized quantitative
measurements with associated units. These data support analysis of
mitochondrial bioenergetics under toxicant exposure conditions and are
suitable for reanalysis. Associated experimental outputs, including
western blot and Southern blot image data used to assess protein
expression and mitochondrial DNA (mtDNA) stability, are available via the
linked Zenodo repository. No human subjects data are included. All data
are de-identified and shared under CC0 (Dryad), with associated image
files available under CC BY (Zenodo).
提供机构:
Dryad
创建时间:
2026-05-12



