A double-blinded placebo-controlled parallel design trial to determine whether inhibiting intestinal sweet taste sensing improves glycaemic responses in patients with type 2 diabetes
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Intestinal sweet taste receptors (STRs) sense all sweet stimuli to coordinate the absorption and metabolism of glucose. A defect in intestinal STRs in patients with type 2 diabetes (T2D), as well as supplementation of low-calorie sweeteners in non-diabetic subjects, both accelerate glucose absorption and worsen glycaemic control. This is a double-blinded placebo-controlled parallel design trial to determine whether inhibiting intestinal sweet taste sensing improves glycaemic responses in patients with type 2 diabetes, by blocking intestinal STRs in patients with T2D.
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