Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro‑1H‑pyrrolo[3,2‑c]pyridin-4(5H)‑ones

An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1H-pyrrolo­[3,2-c]­pyridin-4­(5H)-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly­(ethylene glycol)-400 at 100 °C to afford a series of pyrrolo­[3,2-c]­pyridinone derivatives in good to excellent yields.