A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39 Descriptor: 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM Authors: Knight, Z.A, Gonzalez, B, Feldman, M.E, Zunder, E.R, Goldenberg, D.D, Williams, O, Loewith, R, Stokoe, D, Balla, A, Toth, B, Balla, T, Weiss, W.A, Williams, R.L, Shokat, K.M. Deposit date: 2006-03-16 Release date: 2006-05-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling Cell(Cambridge,Mass.), 125, 2006

磷脂酰肌醇3-激酶（PI3-K）家族的药理学图谱揭示p110α在信号转导中的作用：磷酸肌醇3-激酶γ与抑制剂PIK-39复合物的结构。描述符：2-((9H-嘌呤-6-基硫)甲基)-5-氯-3-(2-甲氧基苯基)喹唑啉-4(3H)-酮、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型。作者：Knight, Z.A.、Gonzalez, B.、Feldman, M.E.、Zunder, E.R.、Goldenberg, D.D.、Williams, O.、Loewith, R.、Stokoe, D.、Balla, A.、Toth, B.、Balla, T.、Weiss, W.A.、Williams, R.L.、Shokat, K.M.。存档日期：2006-03-16。发布日期：2006-05-22。最后修改日期：2023-12-13。实验方法：X射线衍射（2.6 Å）。引用文献：《A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling》，发表于《Cell（剑桥，马萨诸塞州）》，第125卷，2006年。