RNAseq analysis of CC strains after influenza A virus infection identifies genetic control of the host response

Gene expression changes in the lung was studied by RNAseq in different CC mouse strains infected with influenza A virus. Results: Strong differences between the genetically CC mouse strains can be observed in the activation of host defense genes. These differences can be related to genetic variants in the genome of the CC strains. Furthermore, different strains exhibit variant susceptibility to infections (body weight loss and survival). These differences can be correlated to differences in gene expression profiles. Overall design: Female mice from 11 CC mouse strains were infected with mouse-adapted H3N2 virus and lungs were harvested at day3, 5 nd 8 after infection. Total RNA was isolated and mRNA was sequenced.