Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Protein Data Bank Japan2023-12-27 更新2026-03-21 收录

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Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand Descriptor: Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007

抗凋亡蛋白Bcl-2与酰基磺酰胺类配体结合的溶液结构描述符：凋亡调节蛋白Bcl-2，N-[(4-{[1,1-二甲基-2-(苯硫基)乙基]氨基}-3-硝基苯基)磺酰基]-4-(4,4-二甲基哌啶-1-基)苯甲酰胺作者：Bruncko, M.、Oost, T.K.、Belli, B.A.、Ding, H.、Joseph, M.K.、Kunzer, A.、Martineau, D.、McClellan, W.J.、Mitten, M.、Ng, S.C.、Nimmer, P.M.、Oltersdorf, T.、Park, C.M.、Petros, A.M.、Shoemaker, A.R.、Song, X.、Wang, X.、Wendt, M.D.、Zhang, H.、Fesik, S.W.、Rosenberg, S.H.、Elmore, S.W. 存入日期：2006-11-29 发布日期：2007-02-27 最后修改日期：2023-12-27 方法：溶液核磁共振（SOLUTION NMR）引用文献：《开发强效Bcl-2与Bcl-xL双重抑制剂的研究》，《药物化学杂志》（J.Med.Chem.），第50卷，2007年

创建时间：

2006-11-29