Loss of H3.1K27me1 in Arabidopsis confers resistance to Geminivirus by sequestering DNA repair proteins onto host genome [RNA-seq]

Transcriptome-wide association studies (TWAS) to pinpoint enhanced expression of genes involved in DNA repair attributed to viral resistance of atxr5 atxr6. Overall design: To investigate how the transcriptome is reprogramed upon virus infection, we performed comprehensive TWAS with high quality reads from mock-treated and virus-treated samples. Among genes showed enhanced expression upon virus inoculation, we observed that 365 genes that were expressed at higher levels in atxr5 atxr6 compared to Col-0, brca1 atxr5 atxr6, mbd9 atxr5 atxr6 and sac3b atxr5 atxr6, in both mock-treated and virus-inoculated samples. GO analysis classified the top three enriched biological processes into response to DNA damage, DNA repair, and DNA recombination.