Expression Profiling-based Clustering of Healthy Subjects Recapitulates Classifications Defined by Clinical Observation in Chinese Medicine. Homo sapiens

Based on the theory of constitution of Traditional Chinese Medicine (TCM), healthy individuals can be grouped into distinctive types. the global gene expression signature for distinctive constitutions has not been sufficiently explored. Here we examined gene expression profiles from 32 Chinese Han individuals with Yang/Yin deficiency (n=12 each) and Balanced constitutions (n=8). Overall design: Venous blood (8ml) was obtained from each subject. We isolated the peripheral blood mononuclear cells (PBMCs) for extracting RNA.