Case study I: Fidelity of iBLAST in three consecutive time periods.

blastn search was performed on nucleotide sequence databases (nt). At any time instance, the Past database size is the size of the database from the previous time instance. The Present database size is the database size at the present time instance. Delta is the incremental database growth from the previous time instance to the current time instance. NCBI BLAST must be performed on the entire Present database size, while iBLAST only needs to be performed on Delta.