The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58365
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资源简介：
Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. RNAseq was performed in endogenous BCL6-depleted OCI-LY1 cells rescued with either WT or RD mutant BCL6 (N=3 for each group).
创建时间：
2019-05-15
