Identity of ion transporter and associated enzyme genes.

Enzymes and ion transporters known to be involved in CSF secretion. Protein ID from [72]; these ion transporters have been shown to be active in adult choroid plexus; as an example the cellular localization of SLC4A1 is shown in Fig. 3C, D. Gene ID and function from NCBI (http://www.ncbi.nlm.nih.gov/gene). Genes in bold were not detected in either RNA-Seq or Affymetrix datasets. Slc4a7 was only identified in Affymetrix. Slc12a2 (NKCC1) has previously been identified in embryonic mouse choroid plexus as has Slc12a4 (KCC1) [110] and Slc4a10 (NCBE) [111]. Genes underlined have not previously been identified in rat choroid plexus (but cf. with mouse choroid plexus [13]). A comprehensive list is presented in S2. Most of the genes listed here were identified in both RNA-Seq and Affymetrix datasets.