Crystal structure of the transpeptidase domain of PBP2 from the Neisseria gonorrhoeae cephalosporin decreased susceptibility strain 35/02 in complex with boronate inhibitor VNRX-6752

Crystal structure of the transpeptidase domain of PBP2 from the Neisseria gonorrhoeae cephalosporin decreased susceptibility strain 35/02 in complex with boronate inhibitor VNRX-6752 Descriptor: (3R)-3-({(2R)-2-(4-carboxyphenyl)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]acetyl}amino)-2-hydroxy-3,4-dihydro-2H-1,2-benzoxaborinine-8-carboxylic acid, Penicillin-binding protein 2 Authors: Stratton, C.M, Bala, S, Davies, C. Deposit date: 2024-12-05 Release date: 2025-01-22 Last modified: 2026-05-27 Method: X-RAY DIFFRACTION (2.613 Å) Cite: A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae. Nat Microbiol, 11, 2026