Immunity among covid 19 survivors

Background: COVID-19 is a global pandemic that affected millions of people all over the world since 2019. Infection with COVID-19 initiates a humoral immune response that produces antibodies against specific viral antigens which in turn is supposed to provide immunity against reinfection for a period of time. The aim of current research is to study the kinetics of IgM and IgG antibodies against SARS-CoV-2. Method: 117 post COVID-19 participants were enrolled in the study. Qualitative assessment of IgM and IgG antibodies over 6 months (3 visits) post recovery was conducted. Results: Current study revealed significant reduction in IgM and IgG titers between 1st and 2nd visits (p< 0.001). By the end of 6 months, antibody titer declined by 78.8% from 1st visit for IgM and by 49.2% for IgG antibodies. Regarding younger age and male gender, statistically significant persistence of IgM antibodies was noticed at the 6 months follow up. Also, statistically significant persistent IgG immunity was found in male patients and diabetics by the end of 6 months follow up. Conclusion: There was significant waning of IgM and IgG titers over a period of 6 months follow up was observed. The persistence of positive IgM and IgG antibodies by the end of 6 months was variable due to differences in age, gender and presence of diabetes mellitus.