Crystal structure of the human METTL3-METTL14 complex with compound UOZ004

Crystal structure of the human METTL3-METTL14 complex with compound UOZ004 Descriptor: (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Huang, D, Caflisch, A. Deposit date: 2021-02-10 Release date: 2021-09-01 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023

人源METTL3-METTL14复合物结合化合物UOZ004的晶体结构。描述信息：(R)-N-((3-羟基-1-(6-(甲氨基)嘧啶-4-基)哌啶-3-基)甲基)-4-((4-甲基哌啶-1-基)甲基)苯甲酰胺、乙酸根离子、N6-腺苷甲基转移酶催化亚基等。作者：Bedi, R.K、Huang, D、Caflisch, A。沉积日期：2021-02-10；发布日期：2021-09-01；最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.85埃（Å））。引用文献：《m6A-RNA甲基转移酶METTL3抑制剂的基于结构设计》（原标题：Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3），发表于Acs Bio Med Chem Au, 2023。