Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066

Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Descriptor: 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... Authors: Amporndanai, K, O'Neill, P.M, Hong, W.D, Amewu, R.K, Pidathala, C, Berry, N.G, Biagini, G.A, Leung, S.C, Hasnain, S.S, Antonyuk, S.V. Deposit date: 2020-06-17 Release date: 2021-06-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Targeting the ubiquinol-reduction (Qi) site of the mitochondrial cytochrome bc1 complex for the development of next generation quinolone antimalarials To Be Published

牛细胞色素bc1（cytochrome bc1）与喹诺酮类抑制剂RKA066复合物的晶体结构 描述项：1,2-二己酰基-sn-甘油-3-磷酸乙醇胺、1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱、1,2-二油酰基-sn-甘油-3-磷酸乙醇胺…… 作者：Amporndanai, K、O'Neill, P.M、Hong, W.D、Amewu, R.K、Pidathala, C、Berry, N.G、Biagini, G.A、Leung, S.C、Hasnain, S.S、Antonyuk, S.V 提交日期：2020-06-17 发布日期：2021-06-30 最后修改日期：2024-01-24 检测方法：X射线衍射（分辨率3.5 Å） 引用文献：靶向线粒体细胞色素bc1复合物的泛醌还原（Qi）位点以开发新一代喹诺酮类抗疟药物（待发表）