Ache W. CPT-11

Ache W. CPT-11 Descriptor: (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... Authors: Harel, M, Hyatt, J.L, Brumshtein, B, Morton, C.L, Wadkins, R.W, Silman, I, Sussman, J.L, Potter, P.M, Israel Structural Proteomics Center (ISPC) Deposit date: 2004-07-29 Release date: 2005-07-19 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.61 Å) Cite: The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action Mol.Pharmacol., 67, 2005

Ache W. 的CPT-11描述项：(4S)-4,11-二乙基-4-羟基-3,14-二氧代-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-9-基 1,4'-联哌啶-1'-羧酸酯、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、乙酰胆碱酯酶(Acetylcholinesterase)等。作者：Harel, M.、Hyatt, J.L.、Brumshtein, B.、Morton, C.L.、Wadkins, R.W.、Silman, I.、Sussman, J.L.、Potter, P.M.；提交机构：以色列结构蛋白质组学中心(ISPC)。存档日期：2004-07-29；发布日期：2005-07-19；最后修改日期：2024-11-13。实验方法：X射线衍射法（分辨率2.61埃）。引用文献：抗癌前药7-乙基-10-[4-(1-哌啶基)-1-哌啶基]羰氧基喜树碱（CPT-11）与加州电鳐(Torpedo californica)乙酰胆碱酯酶的复合物晶体结构，为其胆碱能作用提供了分子层面阐释，《Mol.Pharmacol.》，67卷，2005年。