Crystal Structure of Macrocycle mediated complex of FKBP12 and MAPRE1

Crystal Structure of Macrocycle mediated complex of FKBP12 and MAPRE1 Descriptor: (5S,14R,16aS,21R,28S,30aR)-14-[2-(3,4-dimethoxyphenyl)ethyl]-24,24,28-trimethyl-2-methylidene-1,3,4,17,18,19,20,24,25,28,29,30a-dodecahydro-2H,14H-9,13-(metheno)dipyrido[1,2-d:1',2'-o][1,10,18,4,7,15]trioxatriazacyclotetracosine-6,16,22,23,27,30(7H,16aH)-hexone, Microtubule-associated protein RP/EB family member 1, Peptidyl-prolyl cis-trans isomerase FKBP1A Authors: King, D.A. Deposit date: 2024-07-16 Release date: 2025-03-26 Last modified: 2025-05-21 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues. Rsc Chem Biol, 6, 2025

大环配体介导的FKBP12与MAPRE1复合物的晶体结构
描述符：(5S,14R,16aS,21R,28S,30aR)-14-[2-(3,4-二甲氧基苯基)乙基]-24,24,28-三甲基-2-亚甲基-1,3,4,17,18,19,20,24,25,28,29,30a-十二氢-2H,14H-9,13-(甲撑)二吡啶并[1,2-d:1',2'-o][1,10,18,4,7,15]三氧三氮杂环四十烷-6,16,22,23,27,30(7H,16aH)-六酮、微管相关蛋白RP/EB家族成员1（Microtubule-associated protein RP/EB family member 1）、肽基脯氨酰顺反异构酶FKBP1A（Peptidyl-prolyl cis-trans isomerase FKBP1A）
作者：King, D.A.
提交日期：2024-07-16
发布日期：2025-03-26
最后修改日期：2025-05-21
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.77 Å
引用文献：FKBP12、MAPRE1与大环分子胶三元复合物的鉴定与表征. Rsc Chem Biol, 6, 2025