Lipid engulfed macrophages interfere with protective T cell immunity and favor tumor progression in human colon carcinogenesis - Monocyte

Obesity and altered lipid metabolism are associated with colorectal cancer (CRC). In this context, the presence of colonic lipid-engulfed macrophages (foam cells, FC) may hinder protective T cell immunity, thus favoring gut carcinogenesis. Triplicate RNASeq was performed on RNA extracted from In vitro-derived FC generated by culturing sorted CD14+ cells from PBMCs of healthy donors with M-CSF stimulating factor. Cells were grown in the absence or presence of oxLDL for 48h.