Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune-regulatory features [RNA-seq]

To understand the site-specific differences in how metastatic pancreatic cancer is modulated, we compared the non-immune compartments by bulk RNA-seq by mouse models of lung and liver metastatic pancreatic cancer based on Kras and Trp53 driven pancreatic cancer cells (KPC). Five groups are compared: In vitro culture of KPC cells (n=8); Dissociated normal lung tissue (n=5); Dissociated normal liver tissue (n=5); Non-immune cells enriched from KPC-bearing lungs (n=5); Non-immune cells enriched from KPC-bearing livers (n=7)