Data underlying the publication: "NaI gamma camera performance for high energies: Effects of crystal thickness, photomultiplier tube geometry and light guide thickness".

This work focused on the study of NaI gamma cameras, with particular attention to scintillator thickness, PMT size and layout, and light guide thickness. The motivation for this study stems from the growing interest in gamma imaging beyond the conventional clinical energy range, for example in theranostic applications and preclinical multi-isotope PET and PET-SPECT imaging. However, standard gamma cameras are typically equipped with 9.5 mm thick NaI crystals, which can lead to limited sensitivity at higher energies. To address this limitation, we investigated the extent to which increasing the scintillator thickness can improve photopeak sensitivity for high-energy isotopes while maintaining acceptable spatial resolution. This led to a systematic study in which different combinations of scintillator thickness, light guide thickness, and PMT type were compared through performance analysis. The collected data include simulation macros, performance analysis scripts, and reconstructed images. All datasets, scripts, and software used in the paper <em>“NaI gamma camera performance for high energies: Effects of crystal thickness, photomultiplier tube geometry and light guide thickness”</em> have been archived. A user manual detailing how to operate the software tools employed in this work is also included.